N15 Tau-441, Uniformly Labeled

Tau is a family of six isoforms, derived from a single gene by alternative mRNA splicing. They vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa), and differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each

Catalog ID: T-1101-1

$550.00

  • Product Details

    • Size: 50 µg
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQGL
    • Source: Recombinant. A DNA sequence encoding the human tau-441 (2N4R isoform) sequence was expressed in E. coli with N15 as the nitrogen source. No his-tag.
    • Purity: >90% by SDS-PAGE
    • Molecular Mass: 46,481 Da theoretical
  • References

    1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
    2. Goedert, M., (1993) Trends Neurosci., 16 : 460
    3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
    4. Goedert, M., et al., (1989) Neuron., 3 : 519
    5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
    6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
    7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412