APO-J / Clusterin

Apoliprotein J (APO-J), also named Clusterin, is a 75-80 kD disulfidelinked heterodimeric protein. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the α and β chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic α -helices. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others

Catalog ID: A-2012-1

$245.00

  • Product Details

    • Size: 10 µg
    • Physical State: Lyophilized from PBS, pH 7.5.
    • Temperature Storage: -20°C
    • Temperature Shipping: Blue Ice
    • Source: Plasma
    • Purity: >95% by SDS-PAGE and HPLC analyses
    • Molecular Mass: 75-80,000 Da