Chymotrypsin, Human Pancreas
Chymotrypsin-like proteasome activities were found to increase in cells treated with 10-100 uM 6-OHDA, while “higher doses caused a marked decline” Such harsh oxidative attacks might cause failure of the ubiquitin-proteasome system (UPS) which leads to protein aggregation and cell death. “Mutations in familial PD have been associated with the failure of protein degradation through UPS”.
- Size: 100 µg
- Physical State: Salt-free lyophilized solid
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Purity: >95% by SDS-PAGE
- Molecular Mass: 25,000 Da
References1. Elkon, H., et al., (2004), J. Molecular Neuroscience, 24(3) : 387-400.