Alpha-Synuclein, 1-122

Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein 1-122 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.

Applications: The Alpha-Synuclein 1-122 is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1025

$300.00 – $550.00

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  • Product Details
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DN
    • Source: Recombinant. A DNA sequence encoding the human Alpha-Synuclein (1-122) sequence was expressed in E. coli
    • Purity: >95% by SDS-PAGE and Mass Spec.
    • Molecular Mass: 12,341 Da theoretical

  • References
    1. McGlinchey, R., et al., (2019) JBC, 294 : 25
    2. Yoo, H., et al., (2022) BMB Reports, 55 : 7
    3. Sorrentino, Z., et al., (2019) JBC, 293 : 49

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