Alpha-Synuclein, Mouse, Desalted

Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein and is a major component of Parkinson’s Disease (PD) aggregates. α-Synuclein is implicated in the pathogenesis of PD and related neurodegenerative disorders. α-Synuclein also accumulates in the brains of sporadic PD patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of PD. α-Synuclein appears to associate with other proteins that aggregate and is found in beta-amyloid plaques and neuritic tangles in Alzheimer’s disease ³. rPeptide offers a wide array of synuclein products, including fragments, mutants, preformed fibrils, and labeled versions in addition to the wild-type protein. Mouse alpha-synuclein has a 95% homologous sequence to human alpha-synuclein. Alpha-synuclein fibrils are prevalent in Lewy bodies, a physiological symptom of Parkinson’s Disease. This product is supplied in a buffer without salt to better fill the needs of customers whose experiments may have interference with NaCl.