FITC Tau-441 Preformed Fibrils

Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.

About the product: While some fluorescent Tau on the market uses intrinsic fluorescence and adds in tryptophan residues by mutations, rPeptide’s human Tau-441 has been covalently labeled with Fluorescein Isothiocyanate. Lysine residues of the native sequence were used as labeling sites, leaving any cysteine residues unaffected. This FITC labeled form of Tau-441 was then formed into fibrils according to rPeptide’s proprietary methods. Fibril formation is determined by TEM and thioflavin assay, while fluorescence is confirmed before fibrillization by end point fluorescence assay and after by LM.

Applications: The FITC Tau-441 Preformed Fibrils are ideal for experimental use or as controls in aggregation kinetics, fibril morphology, seeding experiments, or in vivo imaging.