Alpha-Synuclein 98AA Preformed Fibrils
Product Background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, Alpha-Synuclein 98 is a splicing variant that lacks exons 3 (G41-T54) and 5 (N103-E130) and is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality. This form of human Alpha-Synuclein was then formed into fibrils according to rPeptide’s proprietary methods. Fibril formation is determined by TEM and thioflavin assay.
Applications: The Alpha-Synuclein 98 fibrils are sold in 200mM Tris, 250mM NaCl, pH 7.4 and may be suitable for experimental use or as controls in aggregation kinetics, fibril morphology, seeding experiments, or in vivo imaging.
Price range: $750.00 through $1,200.00
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Product Details
- Physical State: Liquid
- Temperature Storage: -80°C
- Temperature Shipping: Dry Ice
- Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYVVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GK EGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the human alpha-synuclein 98AA sequence was expressed in E. coli and was then made into preformed fibrils.
- Purity: >95%
- Molecular Mass: N/A. See Estimated Size on Data Sheet
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References
- Du, T., et al., (2019), Frontiers in Molecular Neuroscience, 12, 189
- Beyer, K., et al., (2008), Neurogenetics, 9 15-23
- 3. Röntgen, A., et al., (2024) Biophysics and Computational Biology, 121, 7