ISRIB

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Product Name
ISRIB
Size
Catalog #
N-1539-2
Storage
-20°C
Description
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM1. Enhances spatial and fear-associated learning in mice and enhances cognitive function1,2. Mechanism of action involves activation of eiF2β3. Suppresses ER stress-induced inflammatory gene expression4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models6.
Cost (US$)
$240
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1. C Sidrauski et al. Elife 2013 2:e00498
2. Y Sekine et al. Science 2015 348:1027
3. C Sidrauski et al. Elife 2015 4:e07314
4. LN Guthrie et al. J. Biol. Chem. 2016 291:15830