Tau-441

Name: Tau-441
SKU: T-1001-1
Price: 225.00 USD
Availability: InStock

Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.

About the product: Tau-441 is the mature human Tau isoform with 441 amino acids and a mass of 46kDa. Expressed recombinantly in E. coli, Tau-441 is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: rPeptide Tau products can be used for a wide variety of applications including aggregation studies, assay development, fibrillization, and as standards in customer analyses.

Catalog ID: T-1001-1

$225.00

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Product Details
- Size: 50 µg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
  MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Source: Recombinant. A DNA sequence encoding the human tau-441 (2N4R isoform) sequence was expressed in E. coli. No his-tag.
- Purity: >90% by SDS-PAGE
- Molecular Mass: 45,900 Da theoretical
References

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2. Goedert, M., (1993) Trends Neurosci., 16 : 460
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5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412
Publications

Highly sensitive quantification of Alzheimer’s disease biomarkers by aptamer-assisted amplification

Theranostics.; DOI: 10.7150/thno.29232.

Hei-Nga Chan, Di Xu, See-Lok Ho, Dinggeng He, Man Shing Wong, Hung-Wing Li

Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer’s Disease Tangles and can be a Product of the Abl-Related Kinase, Arg.

Journal of Alzheimer’s Disease; DOI: 10.3233/JAD-2010-1271.

Tremblay, Matthew, Acker, Christopher M., Davies, Petera

Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.

Mol Cell Biol.; 2010 Oct; 30 (19) :4626-43. PubMed PMID:20679486; PubMed Central PMCID: PMC2950521.

Eroglu B, Moskophidis D, Mivechi NF.

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models.

The Journal of Biological Chemistry; 2011 Sept 30 The Journal of Biological Chemistry, 286, 34457-34467.2011 Aug 12, doi: 10.1074/jbc.M111.229633.

Chai, X., Wu, S., Murray, T., Kinley, R, Cella, C., Sims, H., Buckner, N., Hanmer, J., Davies, P., O'Neill, M, .Hutton, M.and Citron, M.

Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.

J. Pathol.; 226: 132–142. 2012 Jan; doi: 10.1002/path.2984.

Wilhelmus, M. M., de Jager, M., Rozemuller, A. J., Brevé, J., Bol, J. G., Eckert, R. L. and Drukarch, B.,

New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders.

J Pharm Bioallied Sci.; 2012 Apr-Jun; 4(2): 112–117. doi: 10.4103/0975-7406.9481; PMCID: PMC3341714.

Vasudevaraju, P., Guerrero, E., Hegde, ML, Collen, TB, Britton, GB, and Rao, KS

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease.

J Alzheimers Dis.; doi: 10.3233/JAD-190604.

Huseby, Carol J., Hoffman, Claire N., Cooper, Grace L., Cocuron, Jean-Christophe., Alonso, Ana P., Thomas, Stefani N., Yang, Austin J., Kuret, J.

Highly sensitive quantification of Alzheimer’s disease biomarkers by aptamer-assisted amplification.

Theranostics; DOI: 10.7150/thno.29232.

Hei-Nga Chan, Di Xu, See-Lok Ho, Dinggeng He, Man Shing Wong, Hung-Wing Li

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Science Advances; DOI: 10.1126/sciadv.aau3333.

Stephen S. Dominy, Casey lynch, Florian Ermini, Malgorzata Benedyk, Agata Marczyk,...Jan Potempa

Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression.

Scientific Reports; DOI:10.1038/s41598-018-35130-y.

Hsu-Hsin Chen, Peter Liu, Paul Auger, Seung-Hye Lee, Oskar Adolfsson, Lorianne Rey-Bellet, Julien Lafrance-Vanasse, Brad A. Friedman, Maria Pihlgren, Andreas Muhs, Andrea Pfeifer, James Ernst, Gai Ayalon, Kristin R. Wildsmith, Thomas G. Beach & Marcel P. van der Brug

In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer’s brain.

Prion; https://doi.org/10.1080/19336896.2018.1545524.

Won-Hee Nam & Young Pyo Choi

Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy.

bioRxiv; doi: http://dx.doi.org/10.1101/418640.

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, and Li Gan

Anti-Tau Antibodies Based Electrochemical Sensor for Detection of Tau Protein Biomarkers.

Journal of The Electrochemical Society; DOI: 10.1149/2.0041812jes.

Nicholas Carlin and Sanela Martic-Milne

Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.

Translational Psychiatry; doi: 10.1038/tp.2017.165.

F Biundo, C d'Abramo, M D Tambini, H Zhang, D Del Prete, F Vitale, L Giliberto, O Arancio, & L D'Adamio

Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke.

BMC Neurol.; doi: 10.1186/s12883-017-0945-8.

Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs, Eugeen Namechelen

Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein.

BioMed Central; 10.1186/s40478-017-0435-7.

Richard RubensteinEmail author, Binggong Chang, Natalia Grinkina, Eleanor Drummond, Peter Davies, Meir Ruditzky, Deep Sharma, Kevin Wang and Thomas Wisniewski

Widespread tau seeding activity at early Braak stages.

Acta Neuropathologica; doi: 10.1007/s00401-016-1644-z.

Jennifer L. Furman, Jaime Vaquer-Alicea, Charles L. WhiteIII, Nigel J. Cairns, Peter T. Nelson, Marc I. Diamond

Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain.

Front Neurosci.; DOI: 10.3389/fnins.2016.00504.

Miranda E. Orr, Valentina R. Garbarino, Angelica Salinas, Rochelle Buffenstein

Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson’s Disease Dementia.

PLOS ONE; http://dx.doi.org/10.1371/journal.pone.0164953.

Yannick Kronimus, Alexandra Albus, Monika Balzer-Geldsetzer, Sarah Straub, Elisa Semler, Markus Otto, Jens Klotsche, Richard Dodel ,LANDSCAPE Consortium ,David Mengel

Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke.

BMC Neurology; doi: 10.1186/s12883-017-0945-8.

Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

On-chip microtubule gliding assay for parallel measurement of tau protein species.

Lab Chip; doi: 10.1039/c5lc01486g.

Subhathirai Subramaniyan Parimalam, Mehmet C. Tarhan, Stanislav L. Karsten, Hiroyuki Fujita, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa

Rifampicin is a candidate preventive medicine against amyloid β and tau oligomers.

Oxford University Press; DOI: http://dx.doi.org/10.1093/brain/aww042.

Tomohiro Umeda, Kenjiro Ono, Ayumi Sakai, Minato Yamashita, Mineyuki Mizuguchi, William L. Klein, Masahito Yamada, Hiroshi Mori, Takami Tomiyama

Tau protein, a biomarker of Alzheimer´s disease: in vitro phosphorylation and tau-reactive antibodies characterization.

Charles University; DOI 10.1002/jssc.201501045.

Lenka Hromádková

Depletion of microglia and inhibition of exosome synthesis halt tau propagation.

Nature; doi:10.1038/nn.4132.

Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler & Tsuneya Ikezu

Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report.

ScienceDirect; doi:10.1016/j.exger.2015.04.010.

David A. Loeffler, Lynnae M. Smith, Andrea C. Klaver, Sanela Martić

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models.

PLOS One; DOI: 10.1371/journal.pone.0125614.

Sethu Sankaranarayanan, Donna M. Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S. Rangan, Angela Cacace, Charles F. Albright, Jere Meredith Jr., John Q. Trojanowski, Virginia M-Y. Lee,Kurt R. Brunden, Michael Ahlijanian

Compounds and Compositions for use a Modulators of Tau Aggregation and Alleviation of Tauopathies.

FPO; .

Snow, Alan D.; Hu, Qubai; Lake, Thomas; Cam, Judy

Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry.

Clinical Chemistry; doi: 10.1373/clinchem.2013.216515.

Thomas McAvoy, Michael E. Lassman, Daniel S. Spellman, Zhenlian Ke, Bonnie J. Howell, Oitak Wong, Lan Zhu, Michael Tanen, Arie Struyk, and Omar F. Laterza

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease.

PLoS One; DOI: 10.1371/journal.pone.0076523.

Jere E. Meredith Jr., Sethu Sankaranarayanan, Valerie Guss, Anthony J. Lanzetti, Flora Berisha, Robert J. Neely, J. Randall Slemmon, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Holly Soares, Michael Ahlijanian, Charles F. Albright

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models.

Elsevier Inc.; doi:10.1016/j.neurobiolaging.2012.05.010.

Christopher M. Acker, Stefanie K. Forest, Ray Zinkowski, Peter Davies, Cristina d'Abramo

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models.

Neurobiology of Aging; Volume 33, Issue 8, Pages 1493-1856 (August 2012) DOI 10.1016/j.neurobiolaging.2012.05.010.

Acker, C.M., Forest, S.K., Zinkowski, R., Davies, P., d’Abramco, C.

Tau-441

Product Details

References

Publications

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