Tau-441 Preformed Fibrils
Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.
About the product: Expressed recombinantly in E. coli, human Tau-441 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality. The human Tau-441 is then made into preformed fibrils with their presence and length being confirmed by transmission electron microscopy (TEM) and thioflavin fluorescence assay.
Applications: These human Tau-441 preformed fibrils are sold as a frozen 2mg/mL solution of total protein. The fibrils may be suitable for either in vitro or in vivo requirements such as fibril stability, seeding experiments, aggregation studies, or preformed fibril injections. Tau-441 preformed fibrils may also be used as a neurofibrillary tangle model in any other study of Alzheimer’s Disease.
$225.00 – $1,500.00
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Product Details
- Physical State: Liquid
- Temperature Storage: -80°C
- Temperature Shipping: Dry Ice
- Sequence:
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Source: Recombinant. A DNA sequence encoding the human Tau-441 (2N4R isoform) sequence was expressed in E. coli and was then made into preformed fibrils.
- Purity: >90% by SDS-PAGE
- Molecular Mass: N/A. See Estimated Size on Data Sheet
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References
1. Paul A., et al., (2021) FEBS J. doi: 10.1111/febs.15741
2. Wang, P., Ye, Y., (2021) Nat Commun., 12(1) : 95
3. Veys, L., et al., (2021) Front Aging Neurosci., 12 : 614587 -
Publications
Neuropharmacology (2025) 273, 110455 DOI: 10.1016/j.neuropharm.2025.110455
ApoE3 Christ church and tau interaction as a protective mechanism against Alzheimer’s disease
Alzheimer’s & Dementia (2025), 21 (7), e70396 DOI: 10.1002/alz.70396
Front. Neural Circuits. (2025) 19:1596989. doi: 10.3389/fncir.2025.1596989
