N15 Beta-Synuclein, Uniformly Labeled
Product background: Beta-Synuclein (β-synuclein, 134 amino acids) co-localizes with α-Synuclein in some brain regions but unlike α-Synuclein it is not found in Lewy bodies of Parkinson’s Disease. It has been shown to inhibit the self aggregation of α-Synuclein.
About the product: Expressed recombinantly and isotope labeled in E. coli, human Beta-Synuclein is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: N15 labeled Beta-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be used for NMR structural studies, as a molecular weight standard, a biomarker, and more.
$450.00 – $750.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
- Source: Recombinant. A DNA sequence encoding the human Beta-synuclein sequence was expressed in E. coli, with N15 as the nitrogen source.
- Purity: >95% by SDS-PAGE and Mass Spec
- Molecular Mass: 14,452 Da theoretical
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References
1. Hashimoto, M., et al., (2001) Neuron, 32 : 213
2. Jakes, R., et al., (1994) FEBS Letters, 345 : 27 -
Publications
Relationship of serum beta-synuclein with blood biomarkers and brain atrophy
Alzheimer’s Dement.; doi.org/10.1002/alz.12790
Alzheimers Dement (2025) 21 (4), e70146 DOI: 10.1002/alz.70146
