MLN4924 (Pevonedistat)

Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice. Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma. Modulates tumor microenvironment. Cell permeable

Catalog ID: CV-1006-2

$627.00

  • Product Details

    • Size: 5.0 mg
    • Physical State: White powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 443.2
  • References

    1. Soucy, T.A., et al., (2009) Nature, 458 : 732
    2. Milhollen, M.A., et al., (2010) Blood, 116 : 1515
    3. Zhou, S., et al., (2019) Int. J. Cancer, 145 : 763
    4. Zhou, L., et al., (2019) Mol. Cancer, 18 : 77