Beta-Amyloid (1-42), TFA
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter ion of our Aβ ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$175.00
-
Product Details
- Size: 0.5 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
-
References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029 -
Publications
Alzheimer’s Research & Therapy; doi.org/10.1186/s13195-020-00728-w.
Alzheimer’s & Dementia; doi: 10.1002/trc2.12029.
Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: A pilot study.
bioRxiv; doi: doi.org/10.1101/2020.05.16.093559..
Iron chelators inhibit amyloid-β-induced production of lipocalin 2 in cultured astrocytes ..
Neurochemistry International; doi.org/10.1016/j.neuint.2019.104607.
Acta Neuropathologica Communications; doi.org/10.1186/s40478-020-01013-5.
Hindawi; https://doi.org/10.1155/2019/6403274.
FEBS Open Bio; doi: 10.1002/2211-5463.12156.
Journal of Biological Chemistry; doi: 10.1074/jbc.M115.696229..
Brain; doi: 10.1093/brain/awv318..
The Journal of Neuroscience; 10.1523/JNEUROSCI.0872-14.2014.