Beta-Amyloid (1-42), TFA
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter ion of our Aβ ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$175.00 – $300.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029 -
Publications
Alzheimer’s Dement. 2024; 20: 5940–5960. https://doi.org/10.1002/alz.14044
EMBO Rep (2024) 25 (3), 1233-1255 DOI: 10.1038/s44319-024-00090-0
The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression
Cell Death Dis (2024) 15 (10), 782 DOI: 10.1038/s41419-024-07152-0
J Chromatogr A (2024) 1713, 464531 DOI: 10.1016/j.chroma.2023.464531
Alzheimer’s & Dementia; doi: 10.1002/trc2.12029
Iron chelators inhibit amyloid-β-induced production of lipocalin 2 in cultured astrocytes ..
Neurochemistry International; doi.org/10.1016/j.neuint.2019.104607.
Acta Neuropathologica Communications; doi.org/10.1186/s40478-020-01013-5.
Hindawi; https://doi.org/10.1155/2019/6403274.
Brain; doi: 10.1093/brain/awv318
The Journal of Neuroscience; 10.1523/JNEUROSCI.0872-14.2014.
Molecular and Cellular Neuroscience; http://dx.doi.org/10.1016/j.mcn.2014.05.002
