Beta-Amyloid (1-42), Scrambled

Name: Beta-Amyloid (1-42), Scrambled
SKU: A-1004-1
Price: 220.00 USD
Availability: InStock

Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).

About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42), Scrambled is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: Aβ (1-42), Scrambled is a control peptide with a scrambled amino acid sequence which does not aggregate as native Beta-Amyloid. It is used as a negative control for aggregation assays.

Catalog ID: A-1004-1

$220.00

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Product Details
- Size: 0.5 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
  K V K G L I D G A H I G D L V Y E F M D S N S A I F R E G V G A G H V H V A Q V E F
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid(1-42) scrambled sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
References

1. Yankner, B,A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
5. Hu, J., et al., (1998) Brain Research, 785 : 195-206
Publications

A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation.

Alzheimer’s & Dementia; doi: 10.1002/trc2.12029.

Caneus,J., Akanda, N., Rumsey,J.,Guo, X., Jackson, M., Long, C., Sommerhage, F., Georgieva, S., Kanaan, N., Morgan, D., Hickman, J.

Effects of a Nutritional Supplement on Cognitive Function in Aged Dogs and on Synaptic Function of Primary Cultured Neurons

Animals (Basel).; doi: 10.3390/ani9070393.

Maria Elena Pero, Laura Cortese, Vincenzo Mastellone, Raffaella Tudisco, Nadia Musco, Anna Scandurra, Biagio D’Aniello, Giuseppe Vassalotti, Francesca Bartolini, Pietro Lombardi

Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells.

Neurosci. Bull.; doi: 10.1007/s12264-016-0034-9..

Dema Najem, Michelle Bamji-Mirza, Ze Yang, Wandong Zhang

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.

link.springer.com; https://doi.org/10.1007/s12035-017-0646-8.

Wencel, P.L., Lukiw, W.J., Strosznajder, J.B., Strosznajder, R.P

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer’s disease

Wiley Online Library; |https://doi.org/10.15252/emmm.201708300.

Sophie Steeland , Nina Gorlé , Charysse Vandendriessche , Sriram Balusu , Marjana Brkic , Caroline Van Cauwenberghe , Griet Van Imschoot , Elien Van Wonterghem , Riet De Rycke , Anneke Kremer , Saskia Lippens , Edward Stopa , Conrad E Johanson , Claude Libert , Roosmarijn E Vandenbroucke

Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.

Science Direct; https://doi.org/10.1016/j.bbamcr.2017.11.003.

Czapski,G.A., Cieślik,M., Wencel,P.L., Wójtowicz,S., Strosznajder,R.P., Strosznajder, J.B.

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer.

BioMed Central; 10.1186/s13195-017-0257-7.

Doris Lambracht-Washington Min Fu, Pat Frost and Roger N. Rosenberg

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1–42-mediated cytotoxicity.

FEBS Open Bio; doi: 10.1002/2211-5463.12156.

Cameron, RT.; Whiteley, E.; Day, JP.; Parachikova, AI.; Baillie, GS.

Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice.

Journal of Alzheimer’s Disease; doi: 10.3233/JAD-151136.

Mulder Cornelis K, Dong Yuna, Brugghe Humphrey F, Timmermans Hans A.M, Tilstra, Wichard, Westdijk Janny, van Riet Elly, van Steeg Harry, Hoogerhout Peter, Eisel Ulrich L.M.

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta

BioMed Central; DOI: 10.1186/s12974-016-0484-z.

Ryan C. McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M. Gardeck, Chih-Hao Lee, and Marianne Wessling-Resnick

Hippocampal Injections of Oligomeric Amyloid β-peptide (1–42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway.

Front Aging Neurosci.; doi: 10.3389/fnagi.2015.00245..

Pierre Faucher, Nicole Mons, Jacques Micheau, Caroline Louis, Daniel J. Beracochea

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins.

PLOS One; DOI: 10.1371/journal.pone.0137193.

Magdalena Cieślik, Grzegorz A. Czapski, Joanna B. Strosznajder

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer’s disease

Wiley Online Library; DOI: 10.1111/acel.12281.

Silvia Maioli, Maria Lodeiro, Paula Merino-Serrais, Farshad Falahati, Wasim Khan, Elena Puerta, Alina Codita, Roberto Rimondini, Maria J. Ramirez, Andrew Simmons, Francisco Gil-Bea, Eric Westman, Angel Cedazo-Minguez1, and for the Alzheimer's Disease Neuroimaging Initiative

Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.

Front Aging Neurosci.; https://doi.org/10.3389/fnagi.2014.00237.

Salla Keskitalo, Melinda Farkas, Michael Hanenberg, Anita Szodorai, Luka Kulic, Alexander Semmler, Michael Weller, Roger M. Nitsch, Michael Linnebank

The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death

Science Direct; http://dx.doi.org/10.1016/j.mcn.2014.05.002.

Ryan T. Camerona, Steven D. Quinnb, Lynn S. Cairnsa, Ruth MacLeoda, Ifor D.W. Samuelb, Brian O. Smitha, J. Carlos Penedob, George S. Baillie

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls

PLOS One; DOI: 10.1371/journal.pone.0088604.

Walter Maetzler, Anja Apel, Markus Langkamp, Christian Deuschle, Sarah Selina Dilger, Johannes Georg Stirnkorb, Claudia Schulte, Erwin Schleicher, Thomas Gasser, Daniela Berg

Beta-Amyloid (1-42), Scrambled

Product Details

References

Publications

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