Beta-Amyloid (1-42), E22 Deletion
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) with the E22 deletion is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The HFIP (hexafluoro-isopropanol) counter-ion is a peptide which was purified before being dried with HFIP, leaving a clear dried film rather than a lyophilized powder. The HFIP ensures a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards and more.
$155.00 – $950.00
-
Product Details
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human Beta-Amyloid (1-42)
deletion sequence was expressed in E. coli - Purity: >95% by Mass Spec.
- Molecular Mass: 4,384 Da theoretical
-
References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Novo, M., Freire, S., & Al-Soufi, W., (2018) Sci Rep 8 : 1783
