Beta-Amyloid (1-40), HCl
Beta-amyloid (A-beta) has been long reported as the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is believed by many to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts more than 10% of the population over 65. Recombinantly expressed and sourced from E. coli, rPeptide’s high quality beta-amyloid products offer batch-to-batch consistency and ultrapure starting material for your research needs. The HCl counter-ion is lyophilized in an acidic environment, with what many would consider a more physiologically relevant solution than TFA and may also be less toxic to cell-tissue samples.
$140.00 – $250.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Benoit, S., (2020) Scientific Reports,11 : 6622 -
Publications
Cell Reports (2023) 42 (10), 113240 DOI: 10.1016/j.celrep.2023.113240
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease (2023) 1869 (7), 166793 DOI: 10.1016/j.bbadis.2023.166793
