Beta-Amyloid (1-42), M35V Mutant
Product background: Beta-amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, beta-amyloid (1-42) with the M35V mutation is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter ion ensues a highly monomeric stating material that could be suited to aggregation studies, seeding experiments, molecular standards and more
$100.00
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Product Details
- Size: 100 µg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L V V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence, with a point mutation (M35V), was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,482 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029
