Tau 306

Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.

About the product: The Tau 306 fragment comprises residues 306 to 379, spanning microtubule binding repeats 3 and 4 of Tau with mutations at C322 to serine. Expressed recombinantly in E. coli, Tau 306 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.

Applications: rPeptide Tau products may be used for a wide variety of applications including aggregation experiments, microtubule binding studies and acetyltransferase activity.

Catalog ID: T-1008

$225.00 – $1,875.00

  • Product Details
    • Temperature Storage: –20 C
    • Temperature Shipping: Ambient
    • Sequence:
      MVQIVYKPVD LSKVTSKSGS LGNIHHKPGG GQVEVKSEKL DFKDRVQSKI GSLDNITHVP GGGNKKIETH KLTF
    • Source: Recombinant. Tau 306 is a truncated construct starting at residue 306 to 379 with a C to S mutation at residue 322.
    • Purity: >95% by SDS-PAGE
    • Molecular Mass: 8039 Da theoretical

  • References
    1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
    2. Goedert, M., (1993) Trends Neurosci., 16 : 460
    3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
    4. Goedert, M., et al., (1989) Neuron., 3 : 519
    5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
    6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11

    7.  Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412

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