Tau Protein Ladder
Tau is a family of major neuronal microtubule associated proteins that are found in the neurofibrillary tangles (NFT) in Alzheimer’s disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells. The Tau proteins are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). There are six Tau isoforms, that differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms all derived from a single gene by alternative mRNA splicing.
$100.00
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Product Details
- Size: 50 μl
- Physical State: Solution
- Temperature Storage: -80°C
- Temperature Shipping: Dry Ice
- Source: Recombinant, in E. coli. No his-tag.
- Purity: >90% by SDS-PAGE
- Molecular Mass: 45,900; 42,600; 42,900; 39,700; 40,000; 36,800 theoretical
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References
1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
2. Goedert, M., (1993) Trends Neurosci., 16 : 460
3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
4. Goedert, M., et al., (1989) Neuron., 3 : 519
5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412 -
Publications
Clinical Chemistry; DOI: 10.1373/clinchem.2013.216515.
Frontiers in Molecular Biosciences; doi: 10.3389/fmolb.2020.00048.
Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease.
J Alzheimers Dis.; doi: 10.3233/JAD-190604.
cell.com; https://doi.org/10.1016/j.stemcr.2018.06.022.
http://journals.plos.org; https://doi.org/10.1371/journal.pone.0195771.
Neurobiol Aging; 2009 Mar;30(3):388-93. Epub 2007 Aug 27. PubMed PMID: 17723255; PubMed Central PMCID: PMC2666148.
Expression and silencing of the microtubule-associated protein Tau in breast cancer cells.
Mol Cancer Ther; 2010 Nov; 9 (11) :2970-81. PubMed PMID:21062914.
A novel tau mutation, p.K317N, causes globular glial tauopathy.
Springer Link; doi:10.1007/s00401-015-1425-0.
Universitat de Marburg Library; .
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging.
BMC Neuroscience; doi:10.1186/1471-2202-14-148.