N15 Beta-Amyloid (1-42), Uniformly Labeled
N15 uniformly labeled beta-amyloid peptide (A-beta). A-beta is the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts about 10% of the population over 60.
$110.00
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Product Details
- Size: 0.1 mg
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli with N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,569 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
3. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
4. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536 -
Publications
Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: A pilot study.
bioRxiv; doi: doi.org/10.1101/2020.05.16.093559..Scientific Reports; doi.org/10.1038/s41598-020-69626-3.
Nature Communications; https://doi.org/10.1038/s41467-018-07699-5.Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL
PNAS; https://doi.org/10.1073/pnas.1817477115.Springer Link CNS Drugs; 10.1007/s40263-017-0434-z.Journal of Neurochem.; doi: 10.1111/jnc.13838..Capping of Aβ42 oligomers by small molecule inhibitors
ACS Publications; DOI: 10.1021/bi500910b.