N15 Beta-Amyloid (1-42), Uniformly Labeled
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly and isotope labeled in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The N15 isotopically labeled Aβ (1-42) could be used for NMR structural studies, as a molecular weight standard, a biomarker, and more.
$110.00
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Product Details
- Size: 0.1 mg
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli with N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,569 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
3. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
4. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536 -
Publications
Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: A pilot study.
bioRxiv; doi: doi.org/10.1101/2020.05.16.093559..
Scientific Reports; doi.org/10.1038/s41598-020-69626-3.
Nature Communications; https://doi.org/10.1038/s41467-018-07699-5.
Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL
PNAS; https://doi.org/10.1073/pnas.1817477115.
Springer Link CNS Drugs; 10.1007/s40263-017-0434-z.
Journal of Neurochem.; doi: 10.1111/jnc.13838..
Capping of Aβ42 oligomers by small molecule inhibitors
ACS Publications; DOI: 10.1021/bi500910b.
