FITC Alpha-Synuclein
Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein is covalently labeled with FITC at the side chain of lysine residues and purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The Alpha-Synuclein FITC is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be suited to aggregation studies, binding kinetics, immunofluorescence and more.
$550.00 – $775.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the human Alpha-Synuclein (1-140) sequence was expressed in E. coli and had FITC molecules attached for fluorescence.
- Purity: >95% by SDS-PAGE and Mass Spec.
- Molecular Mass: Approximately 14 kDa to 17kDa
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References
1. Roberti, M., et al., (2007) Nat Methods 4 : 345–351
2. Dusa, A., et al. (2006) Biochemistry 45, 8 : 2752-2760
3. Van Rooijen., B.D. (2009) Journal of Molecular Biology 394, 5, 18 : 826-833
