C13 Beta-Amyloid (1-42), Uniformly Labeled
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly and C13 isotope labeled in E. coli, human Beta-Amyloid (1-42) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: C13 labeled Beta-Amyloid (1-42) is sold in TFA counter-ion to ensure a highly monomeric starting material that may be used for NMR structural studies, as a molecular weight standard, a biomarker, and more.
$1,550.00 – $2,585.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli and uniformly labeled with C13 as the carbon source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,717 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
3. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
4. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536 -
Publications
The Febs Journal; 10.1111/febs.14058.
Pyroglutamylated Amyloid-β Peptide Reverses Cross β-Sheets by a Prion-Like Mechanism
The Journal of Physical Chemistry; DOI: 10.1021/jp412743s.
