Biotin Tau-441
Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.
About the product: The Biotinylated Tau-441 was expressed recombinantly in E. coli and biotinylated at an Avi-tag was added to the C-terminus of the Tau-441 sequence. Biotinylation was verified by ELISA and western blot.
Applications: Biotinylated Tau-441 can serve as a probe in many research applications including immunohistochemistry, localization studies, and affinity assays, without the need for further labeling or a specific antibody.
$550.00 – $3,200.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG LGLNDIFEA QKIEWHE
- Source: Recombinant. A DNA sequence encoding the human Tau-441 (2N4R isoform) sequence was expressed in E. coli and biotinylated on the C-terminus via BirA.
- Purity: >90% by SDS-PAGE
- Molecular Mass: 47,904 Da theoretical
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References
1.Avila, J., et al., (2004) Physiol Rev., 84 : 361 2.Goedert, M., (1993) Trends Neurosci., 16 : 460 3.Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 964.Shivastava, A., et al., (2019) EMBO J, 38(3) : e998715.Roberts, M., et al., (2020) Acta Neuropathol Commun, 8 : 13
