Biotin Beta-Amyloid (1-42), Recombinant
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, the human sequence of Beta-Amyloid (1-42) has an Avi-tag added to the C-terminus for in vivo biotinylation. Biotin Beta-Amyloid (1-42) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The Biotin Beta-Amyloid (1-42) is sold in the NH4OH counter-ion to ensure a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.
$445.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IAGLNDIFEA QKIEWHE
- Source: Recombinant. A DNA sequence encoding the human Beta-Amyloid (1-42) sequence was expressed in E. coli and biotinylated on the C-terminus via BirA.
- Purity: >97% by Mass Spec.
- Molecular Mass: 6558.2 Da Detected by Mass spec. (6569 Da theoretical)
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References
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2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
5. Benoit, S., (2020) Scientific Reports,11 : 6622
6. Shivastava, A., et al., (2019) EMBO J, 38(3) : e99871
7. Roberts, M., et al., (2020) Acta Neuropathol Commun, 8 : 13
