Biotin Alpha-Synuclein

Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, the human sequence of Alpha-Synuclein has an Avi-tag added to the C-terminus for in vivo biotinylation of the protein. Biotin Alpha-Synuclein is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.

Applications: The Biotin Alpha-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1111

$760.00$1,160.00

  • Product Details

    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA GLNDIFEAQK IEWHE
    • Source: Recombinant. DNA sequence encoding the human Alpha-Synuclein sequence was expressed in E. coli and biotinylated on the C-terminus via BirA.
    • Purity: >97% by SDS-PAGE
    • Molecular Mass: 16,515 Da theoretical
  • References

    1. Jensen, P., et al., (1998) J Biol Chem, 273 (41) : 26292-26294
    2. Lee, H., et al., (2011) Biochem Biophys Res Commun, 412 (4) : 526-531
    3. Sevenich, M., et al., (2022) Neurochem Int, 161 : 105422