Beta-Amyloid (1-42) Preformed Fibrils
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, human Beta-Amyloid (1-42) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality. The human Beta-Amyloid is then made into preformed fibrils with their presence and length being confirmed by transmission electron microscopy (TEM) and thioflavin fluorescence assay.
Applications: These human Beta-Amyloid (1-42) fibrils are sold as a frozen 4mg/mL solution of total protein. The fibrils may be suitable for either in vitro or in vivo requirements such as fibril stability, seeding experiments, aggregation studies, or preformed fibril injections. Beta-Amyloid preformed fibrils may also be used as an amyloid plaque model in any other study of Alzheimer’s Disease.
Price range: $200.00 through $2,240.00
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Product Details
- Physical State: Liquid Solution
- Temperature Storage: -80°C
- Temperature Shipping: Dry Ice
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human Beta-Amyloid (1-42) sequence was expressed in E. coli and was then made into preformed fibrils.
- Purity: >97% by Mass Spec.
- Molecular Mass: N/A. See Estimated Size on Data Sheet
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References
1. Kollmer, M., et al., (2019) Nat Commun 10 : 4760
2. Lin, T., et al., (2017) PLoS ONE 12(3)
3. Wang, Q., et al., (2013) ACS Chem Neurosci 4(6) : 1004–1015. -
Publications
Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer’s disease
Cell Commun Signal 23, 472 (2025). DOI: 10.1186/s12964-025-02460-0
Differential amyloid-beta sensitivity across human and nonhuman primate neurons
Journal of Human Evolution (2026), (Vol. 219, 103888). DOI: 10.1016/j.jhevol.2026.103888.