Alpha-Synuclein, Mouse

Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein and is a major component of Parkinson’s Disease (PD) aggregates. α-Synuclein is implicated in the pathogenesis of PD and related neurodegenerative disorders. α-Synuclein also accumulates in the brains of sporadic PD patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of PD. α-Synuclein appears to associate with other proteins that aggregate and is found in beta-amyloid plaques and neuritic tangles in Alzheimer’s disease 3. rPeptide offers a wide array of synuclein products, including fragments, mutants, preformed fibrils, and labeled versions in addition to the wild-type protein. Mouse alpha-synuclein has a 95% homologous sequence to human alpha-synuclein. Alpha-synuclein fibrils are prevalent in Lewy bodies, a physiological symptom of Parkinson’s Disease.

Catalog ID: S-1010-2

$500.00

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  • Product Details
    • Size: 1.0 mg
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA
    • Source: Recombinant. A DNA sequence encoding the mouse alpha-synuclein, was expressed in E. coli.
    • Purity: >95% by SDS-PAGE and Mass Spec.
    • Molecular Mass: 14,485 Da theoretical

  • References

    1. Lashuel, H.A., et. al., (2002), J Mol Biol. 322 : 1089
    2. Park, S.M., et. al., (2002) Blood, 100 : 2506
    3. Polymeropoulos, M.H., et. al., (1997), Science, 276 : 2045

  • Publications

    Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model..

    Alzheimers Dement.; doi: 10.1016/j.jalz.2019.02.002.

    Markus Mandler, Edward Rockenstein, Cassia Overk, Michael Mante, Jazmin Florio, Anthony Adame, Changyoun Kim, Radmila Santic, Achim Schneeberger, Frank Mattner, Sabine Schmidhuber, Gergan Galabova, Brian Spencer, Eliezer Masliah, Robert A.Rissman

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