Alpha-Synuclein, 1-119

Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein 1-119 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.

Applications: The Alpha-Synuclein 1-119 is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1024

$300.00 – $550.00

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  • Product Details
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVD
    • Source: Recombinant. A DNA sequence encoding the human Alpha-Synuclein (1-119) sequence was expressed in E. coli
    • Purity: >95% by SDS-PAGE and Mass Spec.
    • Molecular Mass: 12,014 Da theoretical

  • References
    1. Daher, J., et al., (2009) Molecular Neurodegeneration, 4 : 34
    2. Li, W., et al., (2005) PNAS, 102 : 6
    3. Sorrention, Z., et al., (2020) JBC, 295 : 30

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