Beta-Amyloid (1-42), Mouse, Rat

Beta-amyloid (A-beta) has been long reported as the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is believed by many to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts more than 10% of the population over 65. Recombinantly expressed and sourced from E. coli, rPeptide’s high quality beta-amyloid products offer batch-to-batch consistency and ultrapure starting material for your research needs. The TFA (trifluoro-acetic acid) counter-ion is a peptide which was lyophilized in a final solution containing TFA and is a popular choice for researchers wishing to build on previous studies using this same product. Scrambled peptide is a control peptide which does not aggregate as native beta-amyloid. It is used as a negative control for aggregation.

Catalog ID: A-1008-1

$285.00

  • Product Details

    • Size: 0.5 mg
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      D A E F G H D S G F E V R H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
    • Source: Recombinant. A DNA sequence encoding the mouse/rat beta-amyloid (1-42) sequence was expressed in E. coli
    • Purity: >97% by Mass Spec.
    • Molecular Mass: 4,417Da theoretical
  • References

    1. Yankner, B., et al., (1990) Science, 250 : 279-282
    2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
    3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
    4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029
  • Publications

    Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoring

    bioRxiv; https://doi.org/10.1101/598540.

    Karen E Marshall, Devkee Vadukul, Kevin Staras, Louise C Serpell