Beta Amyloid (1-42), Aggregation Kit
Product background: Beta-amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality. In addition to the Beta-Amyloid (1-42) in NH4OH counter ion, this kit includes reagents to initiate and detect aggregation through thioflavin fluorescence assay.
Applications: The Beta-Amyloid aggregation kit allows for time-based monitoring of the aggregation process through thioflavin fluorescence. Possible roles for this kit may include aggregation kinetics, aggregate stability, or therapeutic models.
$360.00
-
Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
-
References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
5. Benoit, S., (2020) Scientific Reports,11 : 6622 -
Publications
Marine bacterial extracts as a new rich source of drugs against Alzheimer’s disease.
Journal of Neurochemistry; https://doi.org/10.1111/jnc.14847.
