Beta-Amyloid (1-40), TFA
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-40) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter-ion of our Aβ ensures a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.
$120.00 – $200.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human Beta-Amyloid (1-40) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943 -
Publications
The Kinetics of Aggregation of the Aβ1-40 Peptide Monitored by Magnetooptical Methods
Journal of Magnetism and Magnetic Materials (2023) 587, 171273 DOI: 10.2139/ssrn.4492333
J Chromatogr A (2024) 1713, 464531 DOI: 10.1016/j.chroma.2023.464531
Biochim Biophys Acta Mol Basis Dis.; doi: 10.1016/j.bbadis.2016.11.020.
