15N Tau-441 (2N4R) Uniform Labeled

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Product Name
15N Tau-441 (2N4R) Uniform Labeled
Size
Catalog #
T-1101-1
Storage
–20°C
Sequence
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQGL
Source
Recombinant. DNA sequence encoding the human Tau-441 isoform (2N4R) sequence was expressed in E. coli with N15 as the nitrogen source. No his-tag.
Description
Tau is a family of six isoforms, derived from a single gene by alternative mRNA splicing1. They vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa), and differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each2.
Molecular Mass
46,481 Da
Purity
>90% by SDS-PAGE.
Cost (US$)
$550
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1. Himmler, et. al., 1989, Mol Cell Biol. 9, 1381
2. Goedert, M., et. al. 1989, Neuron. 3, 519.
3. Avila J. et. al., 2004, Physiol Rev. 84, 361.
4. Goedert, M., 1993, Trends Neurosci. 16, 460.
5. Mandelkow, E. et al. 1996, Ann N Y Acad Sci. 777, 96.
6. Liu, F., et. al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101, 10804.
7. Iqbal, K., et. al., 1986, Lancet 2, 421.
8. Kopke, et. al., 1993, J. Biol. Chem. 268, 2437