We understand these are trying times and we are here to help keep your research moving forward.

As we closely monitor the situation at hand, rPeptide will remain fully operational and continue to practice all safety protocol while taking precautionary measures to ensure there are no interruptions to your research. From our catalog products to our laboratory services, please let us know how we can assist with your research needs.

Tau-383 Mutant, S262A

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
Tau-383 Mutant, S262A
Size
50ug
Catalog #
T-1016-1
Storage
-20°C
Source
Recombinant, in E. coli. No his-tag.
Description
Tau promotes the assembly and maintains the structure of microtubules in neuronal cells 3,4,5. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms. Tau is both phosphorylated and O-GlcNAcylated 6. The normal brain tau contains 2-3 moles of phosphate/mole of the protein. In Alzheimer disease tau is hyperphosphorylated, containing 3-4-fold more phosphate/mole of the protein than the normal tau 7,8 and is the major protein subunit of paired helical filaments (PHF) that form the neurofibrillary tangles (NFT). NFT accumulation correlates with the clinical progression of Alzheimer's disease. The discovery of close to 20 different mutations in the gene encoding the microtubule-associated protein tau in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has shown that dysfunction of tau protein causes neurodegeneration and dementia9.
Molecular Mass
39.99 kDa
Purity
>90% by SDS-PAGE
Cost (US$)
$300
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.

1. Himmler, et. al., 1989, Mol Cell Biol. 9, 1381
2. Goedert, M., et. al. 1989, Neuron. 3, 519.
3. Avila J. et. al., 2004, Physiol Rev. 84, 361.
4. Goedert, M., 1993, Trends Neurosci. 16, 460.
5. Mandelkow, E. et al. 1996, Ann N Y Acad Sci. 777, 96.
6. Liu, F., et. al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101, 10804.
7. Iqbal, K., et. al., 1986, Lancet 2, 421.
8. Kopke, et. al., 1993, J. Biol. Chem. 268, 2437
9. Spillantini, M.G. et. al., 2000, Neurogenetics, 2, 193.