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Tau-383 Mutant, S262A

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Product Name
Tau-383 Mutant, S262A
Catalog #
Recombinant, in E. coli. No his-tag.
Tau promotes the assembly and maintains the structure of microtubules in neuronal cells 3,4,5. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms. Tau is both phosphorylated and O-GlcNAcylated 6. The normal brain tau contains 2-3 moles of phosphate/mole of the protein. In Alzheimer disease tau is hyperphosphorylated, containing 3-4-fold more phosphate/mole of the protein than the normal tau 7,8 and is the major protein subunit of paired helical filaments (PHF) that form the neurofibrillary tangles (NFT). NFT accumulation correlates with the clinical progression of Alzheimer's disease. The discovery of close to 20 different mutations in the gene encoding the microtubule-associated protein tau in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has shown that dysfunction of tau protein causes neurodegeneration and dementia9.
Molecular Mass
39.99 kDa
>90% by SDS-PAGE
Cost (US$)
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1. Himmler, et. al., 1989, Mol Cell Biol. 9, 1381
2. Goedert, M., et. al. 1989, Neuron. 3, 519.
3. Avila J. et. al., 2004, Physiol Rev. 84, 361.
4. Goedert, M., 1993, Trends Neurosci. 16, 460.
5. Mandelkow, E. et al. 1996, Ann N Y Acad Sci. 777, 96.
6. Liu, F., et. al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101, 10804.
7. Iqbal, K., et. al., 1986, Lancet 2, 421.
8. Kopke, et. al., 1993, J. Biol. Chem. 268, 2437
9. Spillantini, M.G. et. al., 2000, Neurogenetics, 2, 193.