Tau Protein Ladder, of all 6 isoforms

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
Tau Protein Ladder, of all 6 isoforms
Size
Catalog #
T-1007-2
Storage
-70°C
(Ships on Dry Ice)
Source
Recombinant, in E. coli. No his-tag.
Description
Tau is a family of major neuronal microtubule associated proteins that are found in the neurofibrillary tangles (NFT) in Alzheimer's disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells1,2,3. The Tau proteins are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). There are six Tau isoforms, that differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each4. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms all derived from a single gene by alternative mRNA splicing5.
Molecular Mass
45,900, 42,600, 42,900, 39,700, 40,000, 36,800 Da
Purity
>90% by SDS-PAGE.
Cost (US$)
$175
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.

1) Avila J. et. al., 2004, Physiol Rev. 84, 361.
2) Goedert, M., 1993, Trends Neurosci. 16, 460.
3) Mandelkow, E. et al. 1996, Ann N Y Acad Sci. 777, 96.
4) Goedert, M., et. al. 1989, Neuron. 3, 519.
5) Himmler, et. al., 1989, Mol Cell Biol. 9 , 1381