Tau-441, (2N4R)

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Product Name
Tau-441, (2N4R)
Size
Catalog #
T-1001-1
Storage
–20°C
Sequence
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Source
Recombinant. DNA sequence encoding the human Tau-441 isoform (2N4R) sequence was expressed in E. coli. No his-tag.
Description
Tau is a family of major neuronal microtubule associated proteins that are found in the neurofibrillary tangles (NFT) in Alzheimer's disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells1,2,3. The Tau proteins are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). There are six Tau isoforms, that differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each4. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms all derived from a single gene by alternative mRNA splicing5.
Molecular Mass
(441 aa) 45,900 Da
Purity
>90% by SDS-PAGE.
Cost (US$)
$225
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1) Avila J. et. al., 2004, Physiol Rev. 84, 361.
2) Goedert, M., 1993, Trends Neurosci. 16, 460.
3) Mandelkow, E. et al. 1996, Ann N Y Acad Sci. 777, 96.
4) Goedert, M., et. al. 1989, Neuron. 3, 519.
5) Himmler, et. al., 1989, Mol Cell Biol. 9 , 1381