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Alpha-Synuclein, Desalted

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Product Name
Alpha-Synuclein, Desalted
Size
Catalog #
S-1153-1
Storage
-20°C
Source
Recombinant. A DNA sequence encoding the human alpha-synuclein (1-140) sequence was expressed in E. coli.
Description
Alpha-Synuclein (a-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson’s disease aggregates and is implicated in the pathogenesis of Parkinson’s Disease and related neurodegenerative disorders. a-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson’s disease. a-Synuclein appears to associate with other proteins that aggregate and is found in a-amyloid plaques and neuritic tangles in Alzheimer’s disease3. While our catalog product S-1001 is offered in a final buffer containing salt, this product is desalted. After receiving feedback from customers with experiments that can receive interference from salt, we have made this new product in an effort to better fulfill the needs of customers with similar experimental constraints.
Molecular Mass
14,460
Purity
>95% by SDS-PAGE
Cost (US$)
$350
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Quantity

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1) Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
2) Jakes, R. et al. (1994), FEBS Letters, 345: 27
3) Masliah, E. et. al., (2001) Proc. Natl. Acad. Sci., USA, 98: 12245
4) Ueda, K., et. al. (1993) Proc. Natl. Acad. Sci., USA, 90: 11282