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Alpha-Synuclein, Mouse, Desalted

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Product Name
Alpha-Synuclein, Mouse, Desalted
Size
Catalog #
S-1020-2
Storage
-20C
Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Source
Recombinant. A DNA sequence encoding the mouse Alpha-Synuclein, was expressed in E. coli.
Description
Alpha-Synuclein has been linked to autosomal dominant early onset Parkinson’s Disease (PD). Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of PD aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders. Mouse alpha-Synuclein has a 95% homologous sequence to Human Alpha-Synuclein. Alpha Synuclein fibrils are prevalent in Lewy bodies, a physiological symptom of Parkinson’s disease. While our catalog product S-1010 is offered in a final buffer containing salt, this product is desalted. After receiving feedback from customers with experiments that can receive interference from salt, we have made this new product in an effort to better fulfill the needs of customers with similar experimental constraints.
Molecular Mass
14.49kDa by Mass Spec. Analysis (14.48kDa theoretical)
Purity
>95% by SDS-PAGE and Mass Spec.
Cost (US$)
$550
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Quantity

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2) Park, S.M., et. al., (2002) Blood, 100: 2506
3) Polymeropoulos, M.H., et. al., (1997) Science, 276: 2045