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Alpha Synuclein Mouse

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Product Name
Alpha Synuclein Mouse
Size
Catalog #
S-1010-1
Storage
–20⁰C
Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Source
Recombinant. A DNA sequence encoding the mouse alpha-synuclein, was expressed in E. coli.
Description
Alpha-Synuclein has been linked to autosomal dominant early onset Parkinson’s Disease (PD). Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of PD aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders. Mouse alpha-Synuclein has a 95% homologous sequence to Human Alpha-Synuclein. Alpha Synuclein fibrils are prevalent in lewy bodies, a physiological symptom of Parkinson’s disease.
Molecular Mass
14,491 Da by Mass Spec. Analysis ( 14,485.2 Da theoretical)
Purity
>95% by SDS-PAGE and Mass Spec.
Cost (US$)
$300
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Quantity

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1) Lashuel, H.A., et. al., (2002), J Mol Biol. 322: 1089
2) Park, S.M., et. al., (2002) Blood, 100: 2506
3) Polymeropoulos, M.H., et. al., (1997), Science, 276: 2045