Alpha-Synuclein

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Product Name
Alpha-Synuclein
Size
Catalog #
S-1001-1
Storage
–20°C
Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Source
Recombinant. A DNA sequence encoding the human alpha-synuclein (1-140) sequence was expressed in E. coli.
Description
Alpha-Synuclein (a-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson's disease aggregates and is implicated in the pathogenesis of Parkinson's Disease and related neurodegenerative disorders. a-Synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson's disease. a-Synuclein appears to associate with other proteins that aggregate and is found in B-amyloid plaques and neuritic tangles in Alzheimer's disease3.
Molecular Mass
14,460 Da
Purity
>95% by SDS-PAGE and Mass Spec.
Cost (US$)
$300
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1) Conway, K.A. et. al., (2000) Biochemistry, 39: 2552
2) Jakes, R. et al. (1994), FEBS Letters, 345: 27
3) Masliah, E. et. al., (2001) Proc. Natl. Acad. Sci., USA, 98: 12245
4) Ueda, K., et. al. (1993) Proc. Natl. Acad. Sci., USA, 90: 11282