Chymotrypsin-like proteasome activities were found to increase in cells treated with 10-100 uM 6-OHDA, while "higher doses caused a marked decline" 1 Such harsh oxidative attacks might cause failure of the ubiquitin-proteasome system (UPS) which leads to protein aggregation and cell death. "Mutations in familial PD have been associated with the failure of protein degradation through UPS".
>=95% by SDS-PAGE
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1) Elkon, H. et al., (2004), J. Molecular Neuroscience 24(3):387-400.