Alpha 2 Macroglobulin
Alpha 2 Macroglobulin (A2M) seems to play a role in the development of sporadic AD. A2M-D allele was observed as a weak AD protective factor, and the possible interaction of APOE-epsilon 4 and A2M-G alleles may have cause an "increase AD risk in Mainland Han Chinese".
>=95% by SDS-PAGE
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1) Chen D., et al., (2004) J Neurol Sci. Jan 15;217(1):13-5.