Bexarotene

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Product Name
Bexarotene
Size
Catalog #
N-3032-1
Storage
-20°C
Description
A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXR alpha, beta, gamma respectively)1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma2 Causes complete regression of mammary carcinoma3. Bexarotene significantly increases clearance of soluble B-amyloid in a mouse Alzheimer′s model and increases cognitive ability4. Reverses apoE4-driven brain pathology and behavioral deficits in vivo5.
Molecular Mass
348.5
Purity
>98%
Cost (US$)
$70
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Quantity

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1.MF Boehm et al. J. Med. Chem. 1995 38:3146
2.R Gniadecki et al. Br. J. Dermatol. 2007 157:433
3.ED Bischoff et al. Cancer Res. 1998 58:479
4.PE Cramer et al. Science 2012 335:1503
5.A Boehm-Cagan and DM Michaelson J. Neurosci. 2014 34:7293