ANA-12

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Product Name
ANA-12
Size
Catalog #
N-3031-1
Storage
-20°C
Description
TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. Displays antidepressant and anxiolytic properties in mouse models after systemic administration1. Has been used to elucidate the role of BDNF in food intake2, in improvement of cognitive decline during calorie restriction3 and in the discovery of new neurotrophic agents4.
Molecular Mass
407.5
Purity
>98%
Cost (US$)
$87
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1.M Cazorla et al. J. Clin. Invest. 2011 121:1846
2.AM Spaeth et al. Am. J. Physiol. Endocrinol. Metab. 2012 302:E1252
3.T Kishi et al. Int. Heart J. 2015 56:110
4.S Chakravarty et al. Sci. Rep. 2015 5:14134