TRO 19622

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Product Name
TRO 19622
Size
Catalog #
N-3029-1
Storage
-20°C
Description
Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP)1. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage2. Inhibits MPTP opening and protects neurons from apoptosis3. Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model4.
Molecular Mass
399.7
Purity
>98%
Cost (US$)
$55
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1.T Bordet et al. J. Pharmacol. Exp. Ther. 2007 322:709
2.Q Ma et al. Ann. Neurol. 2014 75:209
3.LJ Martin et al. J. Neurosci. 2011 31:359
4.K Magalon et al. Neuropharmacology 2016 111:293