Zileuton

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Product Name
Zileuton
Size
Catalog #
N-3023-1
Storage
-20°C
Description
Reversible inhibitor of 5-Lipoxygenase (IC50 = 500 nM in RBL-1 cells and 300 nM rat PMNLs)1. It also inhibited leukotriene B4 biosynthesis (IC50's = 400nM rat PMNL, 400nM human PMNL)1. Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 μM PGE2 inhibition in LPS-stimulated whole blood)2. Restores memory impairments and reverses amyloid and tau pathology in an Alzheimer’s mouse model3.
Molecular Mass
236.3
Purity
>98%
Cost (US$)
$30
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1.P Waring and J Beaver Gen. Pharmacol. 1996 27:1311
2.LR Fitzpatrick et al. Dig. Dis. Sci. 2000 45:2327
3.A Di Meco et al. Neurobiol. Aging 2014 35:2458