Imatinib Mesylate

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
Imatinib Mesylate
Size
Catalog #
N-3020-1
Storage
-20°C
Description
Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM)1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM)2. It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors as well as several other cancers3. Lowers Amyloid Beta levels by indirect inhibition of gamma-secretase without inhibiting gamma-secretase processing of Notch14.
Molecular Mass
589.7
Purity
>98%
Cost (US$)
$20
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.

1.E Buchdunger et al. Cancer Res. 1996 56:100
2.Heinrich et et al. Blood 2000 96:925
3.M Deininger et al. Pharmacol. Rev. 2003 55:401
4.WJ Netzer et al. Proc. Natl. Acad. Sci. USA 2017 114:1389