DAPT

ORDER ONLINE  •  CALL 866.753.0747  •  FAX 678.753.0746

Product Name
DAPT
Size
Catalog #
N-3018-1
Storage
-20°C
Description
Inhibitor of gamma-secretase (IC50 in human primary neurons = 115 nM for total amyloid beta or 200 nM for Amyloid Beta 42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Amyloid Beta in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3 DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells.4 Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.
Molecular Mass
432.5
Purity
>98%
Cost (US$)
$60
Place an Order
Quantity

Would you like 10 or more?  Save on cost by requesting a Large Quantity Quote.

1. HF Dovey et al. J. Neurochem. 2001 76:173
2. E Portelius et al. Cell Signal 2009 5:615
3. M El Mouedden et al. Curr. Pharma. Des. 2006 12:1671
4. M De Smedt et al. Blood 2005 106:2236
5. JK Ichida et al. Nature Chem. Biol. 2014 10:632