ISO-1

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Product Name
ISO-1
Size
Catalog #
N-3017-1
Storage
-20°C
Description
Antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in mouse asthma model2. Blocks MIF-induced autophagy3. Inhibits experimental autoimmune diabetes in a mouse model, reducing islet antigen-specific proliferative responses and adhesive cell-cell interactions4. Active in cellular and mouse models. Reverses Amyloid Beta-induced toxicity in mouse and human neuronal cell lines5.
Molecular Mass
235.2
Purity
>98%
Cost (US$)
$105
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1. Y Al-Abed et al. J. Biol. Chem. 2005 280:36541
2. PF Chen et al. Mol. Med. 2010 16:400
3. YC Chuang et al. PLoS One 2012 7:e37613
4. I Cvetkovic et al. Endocrinology 2005 146:2942
5. M Bacher et al. Mol. Med. 2010 16:116