SB-225022

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Product Name
SB-225022
Size
Catalog #
N-3016-1
Storage
-20°C
Description
Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors1. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe2. Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages4. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation5.
Molecular Mass
352.14
Purity
>98%
Cost (US$)
$60
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1.JR White et al. J. Biol. Chem. 1998 273:10095
2.M Du et al. PLoS One 2013 8(1):e54572
3.XH Shen et al. Int. Immunopharmacol. 2013 16:261
4.BR Lane et al. J. Virol. 2001 75:8195
5.F Wu et al. J. Neuroinflammation 2015 12:98