Tolcapone

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Product Name
Tolcapone
Size
Catalog #
N-3007-2
Storage
-20°C
Description
Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable. Orally bioavailable.
Molecular Mass
273.2
Purity
>98%
Cost (US$)
$200
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1.PT Manisto et al. Br. J. Pharmacol. 1992 105:569
2.S Di Giovanni et al. J. Biol. Chem. 2010 285:14941
3.R Sant’Anna et al. Nat. Commun. 2016 7:10787
4.SC Forester and JD Lambert J. Funct. Foods 2015 17:183